Science
Discovery
Small molecules are an ideal therapeutic modality to treat both CNS and peripheral diseases. Our expertise in optimizing critical molecular delivery properties enables the parallel development of highly CNS-penetrant and precision-designed peripherally restricted small molecules. This approach unlocks our unique ability to maximize patient impact across a broad array of diseases.
Science
Small molecules are the optimal modality for accessing difficult-to-reach compartments within the human body, particularly for achieving significant and deep brain penetration. Tenvie’s small molecule product engine delivers maximum value creation through a highly validated, CNS-centric approach that produces both CNS and peripheral assets for clinical development optionality.
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Therapeutic Areas
STRATEGIC APPROACH
Neurological
Neurological disease is a complex process driven by inflammation, metabolic disruption, and lysosomal dysfunction
Ophthalmology
Diseases caused by damage to the optic nerve, retina, and other compartments of the eye share many similarities with neurological diseases, including biological drivers and promising therapeutic targets, offering a synergistic approach to therapeutic discovery
Metabolic Syndrome
Neuroinflammation can trigger systemic metabolic dysregulation, thereby contributing to cardiometabolic and cardiovascular disease
Cardiometabolic Disease
Cardiometabolic diseases share common biological underpinnings with many neurological diseases, including inflammation and metabolic dysfunction
Peripheral Neurology
Damage to neurons through metabolic stress, chemotherapy, physical damage, and other challenges leads to degeneration and neuronal loss causing neuropathies and other diseases
Peripheral Inflammation
Peripheral and CNS inflammatory diseases share biological drivers and are governed by many of the same pathways providing the opportunity to realize broad disease impact across inflammatory disease
Core Biological Pillars
Resolve Inflammation
Rescue Metabolic Dysfunction
Restore Lysosomal Function
Drug Discovery
Unlock access to privileged CNS space via precision engineering & disciplined tuning of key properties
Maximize value by derivatizing CNS chemotypes to rapidly deliver peripheral assets
Translation
Targeted & unbiased identification of target- & pathway-specific biomarkers
Biomarker validation to support mechanism of action, indication & patient selection
Science
Small molecules are the optimal modality for accessing difficult-to-reach compartments within the human body, particularly for achieving significant and deep brain penetration. Tenvie’s small molecule product engine delivers maximum value creation through a highly validated, CNS-centric approach that produces both CNS and peripheral assets for clinical development optionality.
text for more detail
Therapeutic Areas
KEY
01 Neurological
Neurological disease is a complex process driven by inflammation, metabolic disruption, and lysosomal dysfunction
02 Ophthalmology
Diseases caused by damage to the optic nerve, retina, and other compartments of the eye share many similarities with neurological diseases, including biological drivers and promising therapeutic targets, offering a synergistic approach to therapeutic discovery
03 Metabolic Syndrome
Neuroinflammation can trigger systemic metabolic dysregulation, thereby contributing to cardiometabolic and cardiovascular disease
04 Cardiometabolic Disease
Cardiometabolic diseases share common biological underpinnings with many neurological diseases, including inflammation and metabolic dysfunction
05 Peripheral Neurology
Damage to neurons through metabolic stress, chemotherapy, physical damage, and other challenges leads to degeneration and neuronal loss causing neuropathies and other diseases
06 Peripheral Inflammation
Peripheral and CNS inflammatory diseases share biological drivers and are governed by many of the same pathways providing the opportunity to realize broad disease impact across inflammatory disease
STRATEGIC APPROACH
Resolve Inflammation
Rescue Metabolic Dysfunction
Restore Lysosomal Function
Unlock access to privileged CNS space via precision engineering & disciplined tuning of key properties
Maximize value by derivatizing CNS chemotypes to rapidly deliver peripheral assets
Targeted & unbiased identification of target- & pathway-specific biomarkers
Biomarker validation to support mechanism of action, indication & patient selection
Breakthrough Research in Small Molecule Therapies