Science
Discovery
Small molecules are the optimal therapeutic modality for expanding the druggable universe and improving healthspan for patients and caregivers. The continuous collaboration between our medicinal chemistry, translational biology, platform discovery, computational science, and pharmacology groups fuels our innovative pipeline.
Science
Small molecules are the most validated modality for accessing difficult-to-reach systems within the body, including the central nervous system (CNS). Tenvie leverages disciplined small molecule engineering to create highly CNS-penetrant and peripherally restricted therapeutics that definitively test therapeutic hypotheses in patients.
Due to the challenges inherent in molecular design and delivery, the medical field is only recently beginning to witness the full potential of small molecules. We believe that foundational biology and biomarkers are inseparable from developing novel treatment with optimized small molecules; our tenacious pursuit of this principle will enable our team to revolutionize medicine.
Therapeutic Areas
STRATEGIC APPROACH
Neurological
Neurodegeneration is a complex process driven by inflammation, metabolic disruption, and lysosomal dysfunction
Ophthalmology
Diseases caused by damage to the optic nerve, retina, and other compartments of the eye share many similarities with neurological diseases, including biological drivers and promising therapeutic targets, offering a synergistic approach to therapeutic discovery
Metabolic Syndrome
Neuroinflammation can trigger systemic metabolic dysregulation, thereby contributing to cardiometabolic and cardiovascular disease
Cardiovascular Disease
Cardiovascular diseases share common biological underpinnings as many neurological diseases, including inflammation and metabolic dysfunction
Peripheral Neurology
Damage to neurons through metabolic stress, chemotherapy, and physical damage among other challenges leads to degeneration and neuronal loss causing neuropathies and other diseases
Peripheral Inflammation
Peripheral and CNS inflammatory diseases share biological drivers and are governed by many of the same pathways providing the opportunity to realize broad disease impact across inflammatory disease
Core Biological Pillars
Resolve Inflammation
Rescue Metabolic Dysfunction
Restore Lysosomal Function
Drug Discovery
Unlock access to privileged CNS space via precision engineering & disciplined tuning of key properties
Maximize value by derivatizing CNS chemotypes to rapidly deliver peripheral assets
Translation
Targeted & unbiased identification of target- & pathway-specific biomarkers (BMs)
BM validation to support mechanism of action, indication & patient selection
Science
Small molecules are the most validated modality for accessing difficult-to-reach systems within the body, including the central nervous system (CNS). Tenvie leverages disciplined small molecule engineering to create highly CNS-penetrant and peripherally restricted therapeutics that definitively test therapeutic hypotheses in patients.
Due to the challenges inherent in molecular design and delivery, the medical field is only recently beginning to witness the full potential of small molecules. We believe that foundational biology and biomarkers are inseparable from developing novel treatment with optimized small molecules; our tenacious pursuit of this principle will enable our team to revolutionize medicine.
Therapeutic Areas
KEY
01 Neurological
Neurodegeneration is a complex process driven by inflammation, metabolic disruption, and lysosomal dysfunction
02 Ophthalmology
Diseases caused by damage to the optic nerve, retina, and other compartments of the eye share many similarities with neurological diseases, including biological drivers and promising therapeutic targets, offering a synergistic approach to therapeutic discovery
03 Metabolic Syndrome
Neuroinflammation can trigger systemic metabolic dysregulation, thereby contributing to cardiometabolic and cardiovascular disease
04 Cardiovascular Disease
Cardiovascular diseases share common biological underpinnings as many neurological diseases, including inflammation and metabolic dysfunction
05 Peripheral Neurology
Damage to neurons through metabolic stress, chemotherapy, and physical damage among other challenges leads to degeneration and neuronal loss causing neuropathies and other diseases
06 Peripheral Inflammation
Peripheral and CNS inflammatory diseases share biological drivers and are governed by many of the same pathways providing the opportunity to realize broad disease impact across inflammatory disease
STRATEGIC APPROACH
Resolve Inflammation
Rescue Metabolic Dysfunction
Restore Lysosomal Function
Unlock access to privileged CNS space via precision engineering & disciplined tuning of key properties
Maximize value by derivatizing CNS chemotypes to rapidly deliver peripheral assets
Targeted & unbiased identification of target- & pathway-specific biomarkers (BMs)
BM validation to support mechanism of action, indication & patient selection
The Details
2024
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
Co-authored by Tenvie Biologists and Platform Technologies.
Published in Cell